PhD Position - Electronic nose development for the early and noninvasive diagnostic of human pathologies by volatile organic compounds analysis in exhaled breath
Employeur : IMT Lille-Douai
The Department of "Atmospheric Sciences and Environmental Engineering" (SAGE) of the Institute Mines Telecom Lille Douai, France (http://www.mines-douai.fr/, http://sage.minesdouai.fr/), has ongoing research activities focused on atmospheric chemistry, air quality and the impacts of human activities on atmospheric composition. SAGE is currently composed of a staff of about 55 persons including 16 full-time faculty members. Research projects aim at a better understanding of the physical and chemical processes involved in the formation, transport and aging/transformation of gaseous and particulate pollutants in the indoor and outdoor atmospheres. One major activity of the SAGE department consist also to develop novel methods to measure trace gases in air. So, the experience acquired in the field of air quality opens new perspectives in the field of health and particularly in the early medical diagnosis.
Context and description of the project:
This thesis is part of the European territorial cooperation programme INTERREG France-Wallonia-Vlaanderen: This programme aims to promote economic and social exchanges between four border regions: the Hauts-de-France and Grand Est regions in France; Wallonia, West and East Flanders in Belgium. It aims to combine common skills while enhancing the wealth of each region concerned, for
the benefit of the people of the area.
The project brings together 12 partners on both sides of the French-Belgian border, including medical teams, specialists in data mining, analytical chemistry, nanomaterials, electronic gas sensors, electronics and signal processing and electronic nose. The priorities of the programme are: increasing research and
innovation in the cross-border area in strategic sectors and sectors with strong complementarity research, innovation and technology transfer.
The thesis work is therefore part of a collaborative project to design innovative tools for early and noninvasive diagnosis of pathologies in the form of an electronic nose able to detect, in patients' breath, biomarkers characteristic of diseases such as lung or breast cancers. For example, the survival of bronchopulmonary cancer is 80% to 5 years by early screening and 15% in case of late diagnosis. The
project has therefore very significant societal impacts.
From a list of volatile organic compounds (VOCs), biomarkers, obtained on a sample of 2000 patients by analytical chemistry methods and sophisticated data processing, the doctoral student will develop nanocomposites from conductive polymers, graphene or carbon nanotubes to fabricate surfaces sensitive to different biomarkers. From the materials developed, sensor networks will be manufactured by different methods (inkjet printing, electrospinning...) to be characterized in the laboratory to evaluate their metrological performances. In addition to traditional material characterizations (SEM, TEM, IR spectrum, conductivity...), the sensor network will be evaluated to determine the VOC footprint of a breath of a non-ill patient and patients with a given pathology. Learning and recognition algorithms will
need to be developed. This part of the work will be carried out in close collaboration with the project partners (KU Leuven, University of Mons, Ulg LiĂ¨ge, University of Lille). Work will also be carried out with the University of Reims to integrate sensitive surfaces into transistors.
This work should lead to the development of an initial prototype which will be evaluated not only in the laboratory but also with patients under the authority of medical teams (CHU Lille).
Keywords: early diagnosis, cancer, nanocomposites, electronic sensors, algorithms, electronic nose
Laboratory: SAGE-IMT Lille Douai, Organic Electronic Sensors Team Academic supervision Prof. JL. Wojkiewicz (SAGE), Dr.N.redon (SAGE)
Doctoral School : Sciences Pour lâ€™IngĂ©nieur (SPI â€“ UniversitĂ© Lille)
Appointment: The Ph.D. fellowship is a fixed-terme position available for a total duration of 3 years with a starting date on November 2018 (~1550 â‚¬ / month with funding FEDER (INTEREG Program) - IMT Lille Douai
Profil / Qualifications Requises
Candidate profile: Holder of a master's degree in materialsâ€™ science with strong competence in organic chemistry. Skills in data processing and electronic sensors are required. The candidate must be able to evolve in a multidisciplinary context and international collaboration with a strong adaptability. A good practice of English is needed.
Job application: Applicants are invited to send (i) their curriculum Vitae and a cover letter and (ii) a recommendation letter and at least one reference of previous or current employer(s)/supervisor(s), to: Â· Pr. Jean-Luc WOJKIEWICZ DĂ©partement Sciences de lâ€™AtmosphĂ¨re et GĂ©nie de lâ€™Environnement IMT Lille Douai Douai 941 rue Charles Bourseul, CS 10838, 59508 Douai Cedex, France Tel : (33) 3 27 71 23 33 / Fax : (33) 3 27 71 29 14 E-mail : [email protected] Â· Dr Nathalie Redon DĂ©partement Sciences de lâ€™AtmosphĂ¨re et GĂ©nie de lâ€™Environnement IMT Lille Douai Douai 941 rue Charles Bourseul, CS 10838, 59508 Douai Cedex, France Tel : (33) 3 27 71 24 77 / Fax : (33) 3 27 71 29 14 E-mail : [email protected]