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PhD Student in Epigenetics

Employeur : Virginie De Landsheer

Job Location


Publish date


Doctorat en:

Master’s degree (or equivalent) in Molecular Biology or Genetics

Job Description:

In the context of the FNR / ANR (France) funded project “MADAM”, addressing the pathomechanisms underlying comorbid depression and diabetes, Dr Jonathan Turner, PI Immune Endocrine Epigenetics Research group, is looking to recruit a :

PhD Student in Epigenetics

3 year fixed-term contract (up to 4 years), full time



Type 2 Diabetes (T2D) and depression often occur together, and there is increasing evidence that they share pathophysiological and mechanistic origins, particularly based in inflammatory cytokine-mediated innate immunity, and/or the hypothalamus-pituitary-adrenal axis.

Epigenetic processes such as DNA methylation integrate the environment and inherited traits to predispose individuals to diseases. For T2D and depression, the evidence is growing that disease loci are epigenetically regulated, and that epigenotypes may be transmitted from one generation to the next and play a significant role in disease development. This PhD Student position, in the Immune Endocrine Epigenetics Research Group, aims to unravel the mechanisms underlying the link between T2D and depression in preclinical epigenetic models of non-obese T2D. Additionally, we will identify the contribution of epigenetic factors in the emergence of anxious-depressive phenotype in diabetic subjects, and whether the anxious-depressive phenotype in diabetic subjects is reversible by strategies targeting HPA axis dysfunctions.

Profil / Qualifications Requises

Key Skills, Experience and Qualifications

  • Master’s degree (or equivalent) in Molecular Biology or Genetics. Prior experience in epigenetics and DNA methylation would be an advantage, but is not mandatory.
  • Good communication would be necessary to deal with the different partners involved in this project at the international level, as well as for restitution of the results to partners
  • Excellent time management, rigor, perseverance, scientific creativity and originality, writing skills, conciseness, sense of priority and ability to work with others.
  • IT skills: Office, Outlook, Endnote if needed.
  • Fluency in English is mandatory, French would be an asset.


Applications including a cover letter and a full curriculum vitae should be sent before 30 November 2017 through our website www.lih.lu/jobs. Ref.: VD/PHDS1017/JT/DII ALL6


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